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apalutamide will decrease the extent or result of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medicines that are CYP3A4 substrates may end up in lessen publicity to these remedies.It works inside the central nervous process pl